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The role of the Zn(II) binding domain in the mechanism of E. coli DNA topoisomerase I
BACKGROUND: Escherichia coli DNA topoisomerase I binds three Zn(II) with three tetracysteine motifs which, together with the 14 kDa C-terminal region, form a 30 kDa DNA binding domain (ZD domain). The 67 kDa N-terminal domain (Top67) has the active site tyrosine for DNA cleavage but cannot relax neg...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC115839/ https://www.ncbi.nlm.nih.gov/pubmed/12052259 http://dx.doi.org/10.1186/1471-2091-3-13 |