Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases

BACKGROUND: Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activating V599E and V599K transitions. METHODS: We here inv...

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Detalles Bibliográficos
Autores principales: Deichmann, Martin, Thome, Marianne, Benner, Axel, Kirschner, Martin, Hassanzadeh, Judith, Kurzen, Hjalmar
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1164406/
https://www.ncbi.nlm.nih.gov/pubmed/15935100
http://dx.doi.org/10.1186/1471-2407-5-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1164406/
https://www.ncbi.nlm.nih.gov/pubmed/15935100
http://dx.doi.org/10.1186/1471-2407-5-58

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