Mutational analysis of human profilin I reveals a second PI(4,5)-P(2) binding site neighbouring the poly(L-proline) binding site

BACKGROUND: Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P(2)). Crystallography, NMR and mutagenesis of vertebrate profilins have revealed the amino acid residues that are responsible for the interaction...

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Detalles Bibliográficos
Autores principales: Lambrechts, Anja, Jonckheere, Veronique, Dewitte, Daisy, Vandekerckhove, Joel, Ampe, Christophe
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116585/
https://www.ncbi.nlm.nih.gov/pubmed/12052260
http://dx.doi.org/10.1186/1471-2091-3-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116585/
https://www.ncbi.nlm.nih.gov/pubmed/12052260
http://dx.doi.org/10.1186/1471-2091-3-12

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