Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities

BACKGROUND: HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element for RT dimerization (Pandey et al., Biochemistry 40: 9505, 2001). Deletion or alanine substitution of four amino acid residues of this...

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Detalles Bibliográficos
Autores principales: Pandey, Pradeep K, Kaushik, Neerja, Singh, Kamalendra, Sharma, Bechan, Upadhyay, Alok K, Kumar, Suriender, Harris, Dylan, Pandey, Virendra N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117134/
https://www.ncbi.nlm.nih.gov/pubmed/12086585
http://dx.doi.org/10.1186/1471-2091-3-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117134/
https://www.ncbi.nlm.nih.gov/pubmed/12086585
http://dx.doi.org/10.1186/1471-2091-3-18

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