A novel method of screening thrombin-inhibiting DNA aptamers using an evolution-mimicking algorithm

Thrombin-inhibiting DNA aptamers have already been obtained through the systematic evolution of ligands by exponential enrichment (SELEX). However, SELEX is a method that screens DNA aptamers that bind to their target molecules, and it sometimes fails to screen good inhibitors. Therefore, it is nece...

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Detalles Bibliográficos
Autores principales: Ikebukuro, Kazunori, Okumura, Yuji, Sumikura, Koichi, Karube, Isao
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174901/
https://www.ncbi.nlm.nih.gov/pubmed/16002787
http://dx.doi.org/10.1093/nar/gni108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174901/
https://www.ncbi.nlm.nih.gov/pubmed/16002787
http://dx.doi.org/10.1093/nar/gni108

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