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A novel method of screening thrombin-inhibiting DNA aptamers using an evolution-mimicking algorithm
Thrombin-inhibiting DNA aptamers have already been obtained through the systematic evolution of ligands by exponential enrichment (SELEX). However, SELEX is a method that screens DNA aptamers that bind to their target molecules, and it sometimes fails to screen good inhibitors. Therefore, it is nece...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174901/ https://www.ncbi.nlm.nih.gov/pubmed/16002787 http://dx.doi.org/10.1093/nar/gni108 |