Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity

Autoantibodies directed against citrulline-containing proteins have an impressive specificity of nearly 100% in patients with rheumatoid arthritis and have been suggested to be involved in the disease pathogenesis. The targeted epitopes are generated by a post-translational modification catalysed by...

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Detalles Bibliográficos
Autores principales: Lundberg, Karin, Nijenhuis, Suzanne, Vossenaar, Erik R, Palmblad, Karin, van Venrooij, Walter J, Klareskog, Lars, Zendman, AJW, Harris, Helena Erlandsson
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174941/
https://www.ncbi.nlm.nih.gov/pubmed/15899032
http://dx.doi.org/10.1186/ar1697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174941/
https://www.ncbi.nlm.nih.gov/pubmed/15899032
http://dx.doi.org/10.1186/ar1697

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