NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone

Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that plays an important role in a variety of infectious and autoimmune disorders. Its transcription is regulated in a stimulus- and cell-type-specific manner via the recruitment of distinct DNA/activator complexes forming secondary structure...

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Autores principales: Esensten, Jonathan H., Tsytsykova, Alla V., Lopez-Rodriguez, Cristina, Ligeiro, Filipa A., Rao, Anjana, Goldfeld, Anne E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175021/
https://www.ncbi.nlm.nih.gov/pubmed/16027109
http://dx.doi.org/10.1093/nar/gki701
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author Esensten, Jonathan H.
Tsytsykova, Alla V.
Lopez-Rodriguez, Cristina
Ligeiro, Filipa A.
Rao, Anjana
Goldfeld, Anne E.
author_facet Esensten, Jonathan H.
Tsytsykova, Alla V.
Lopez-Rodriguez, Cristina
Ligeiro, Filipa A.
Rao, Anjana
Goldfeld, Anne E.
author_sort Esensten, Jonathan H.
collection PubMed
description Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that plays an important role in a variety of infectious and autoimmune disorders. Its transcription is regulated in a stimulus- and cell-type-specific manner via the recruitment of distinct DNA/activator complexes forming secondary structures or enhanceosomes. NFATp, a member of the nuclear factor of activated T cells (NFAT) family of transcription factors, plays a critical role in TNF gene regulation under a variety of conditions. In this study, we show that NFAT5, the most recently described NFAT family member, binds to the TNF promoter in a manner distinct from other NFAT proteins and is a key mediator in the activation of TNF gene transcription during hypertonic stress alone.
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spelling pubmed-11750212005-07-13 NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone Esensten, Jonathan H. Tsytsykova, Alla V. Lopez-Rodriguez, Cristina Ligeiro, Filipa A. Rao, Anjana Goldfeld, Anne E. Nucleic Acids Res Article Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that plays an important role in a variety of infectious and autoimmune disorders. Its transcription is regulated in a stimulus- and cell-type-specific manner via the recruitment of distinct DNA/activator complexes forming secondary structures or enhanceosomes. NFATp, a member of the nuclear factor of activated T cells (NFAT) family of transcription factors, plays a critical role in TNF gene regulation under a variety of conditions. In this study, we show that NFAT5, the most recently described NFAT family member, binds to the TNF promoter in a manner distinct from other NFAT proteins and is a key mediator in the activation of TNF gene transcription during hypertonic stress alone. Oxford University Press 2005 2005-07-12 /pmc/articles/PMC1175021/ /pubmed/16027109 http://dx.doi.org/10.1093/nar/gki701 Text en © The Author 2005. Published by Oxford University Press. All rights reserved
spellingShingle Article
Esensten, Jonathan H.
Tsytsykova, Alla V.
Lopez-Rodriguez, Cristina
Ligeiro, Filipa A.
Rao, Anjana
Goldfeld, Anne E.
NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone
title NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone
title_full NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone
title_fullStr NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone
title_full_unstemmed NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone
title_short NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone
title_sort nfat5 binds to the tnf promoter distinctly from nfatp, c, 3 and 4, and activates tnf transcription during hypertonic stress alone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175021/
https://www.ncbi.nlm.nih.gov/pubmed/16027109
http://dx.doi.org/10.1093/nar/gki701
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