Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes

Interleukin-1 (IL-1), IL-17 and tumor necrosis factor alpha (TNF-α) are the main proinflammatory cytokines implicated in cartilage breakdown by matrix metalloproteinase (MMPs) in arthritic joints. We studied the impact of an anti-neoplastic antibiotic, mithramycin, on the induction of MMPs in chondr...

Descripción completa

Detalles Bibliográficos
Autores principales: Liacini, Abdelhamid, Sylvester, Judith, Li, Wen Qing, Zafarullah, Muhammad
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175029/
https://www.ncbi.nlm.nih.gov/pubmed/15987479
http://dx.doi.org/10.1186/ar1735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175029/
https://www.ncbi.nlm.nih.gov/pubmed/15987479
http://dx.doi.org/10.1186/ar1735

Ejemplares similares