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Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes

Interleukin-1 (IL-1), IL-17 and tumor necrosis factor alpha (TNF-α) are the main proinflammatory cytokines implicated in cartilage breakdown by matrix metalloproteinase (MMPs) in arthritic joints. We studied the impact of an anti-neoplastic antibiotic, mithramycin, on the induction of MMPs in chondr...

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Detalles Bibliográficos
Autores principales:	Liacini, Abdelhamid, Sylvester, Judith, Li, Wen Qing, Zafarullah, Muhammad
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175029/ https://www.ncbi.nlm.nih.gov/pubmed/15987479 http://dx.doi.org/10.1186/ar1735

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