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Histone deacetylases – a new target for suppression of cartilage degradation?
Increased expression of metalloproteinases is a fundamental aspect of arthritispathology and its control is a major therapeutic objective. In cartilage cultured in the presence of the cytokines interleukin-1 and oncostatin M, chondrocytes produce enhanced levels of metalloproteinases of the ADAMTS (...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175048/ https://www.ncbi.nlm.nih.gov/pubmed/15987498 http://dx.doi.org/10.1186/ar1781 |