Inhibition of sarcoplasmic Ca(2+)-ATPase increases caffeine- and halothane-induced contractures in muscle bundles of malignant hyperthermia susceptible and healthy individuals

BACKGROUND: Malignant hyperthermia (MH) is triggered by halogenated anaesthetics and depolarising muscle relaxants, leading to an uncontrolled hypermetabolic state of skeletal muscle. An uncontrolled sarcoplasmic Ca(2+ )release is mediated via the ryanodine receptor. A compensatory mechanism of incr...

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Detalles Bibliográficos
Autores principales: Schuster, Frank, Müller, Rainer, Hartung, Edmund, Roewer, Norbert, Anetseder, Martin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175794/
https://www.ncbi.nlm.nih.gov/pubmed/15946384
http://dx.doi.org/10.1186/1471-2253-5-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175794/
https://www.ncbi.nlm.nih.gov/pubmed/15946384
http://dx.doi.org/10.1186/1471-2253-5-8

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