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Inhibition of sarcoplasmic Ca(2+)-ATPase increases caffeine- and halothane-induced contractures in muscle bundles of malignant hyperthermia susceptible and healthy individuals
BACKGROUND: Malignant hyperthermia (MH) is triggered by halogenated anaesthetics and depolarising muscle relaxants, leading to an uncontrolled hypermetabolic state of skeletal muscle. An uncontrolled sarcoplasmic Ca(2+ )release is mediated via the ryanodine receptor. A compensatory mechanism of incr...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175794/ https://www.ncbi.nlm.nih.gov/pubmed/15946384 http://dx.doi.org/10.1186/1471-2253-5-8 |