HnRNP H inhibits nuclear export of mRNA containing expanded CUG repeats and a distal branch point sequence

Myotonic dystrophy type 1 (DM1) is an autosomal dominant neuromuscular disorder associated with a (CUG)n expansion in the 3′-untranslated region of the DMPK (DM1 protein kinase) gene. Mutant DMPK mRNAs containing the trinucleotide expansion are retained in the nucleus of DM1 cells and form discrete...

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Detalles Bibliográficos
Autores principales: Kim, Dong-Ho, Langlois, Marc-Andre, Lee, Kwang-Back, Riggs, Arthur D., Puymirat, Jack, Rossi, John J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176012/
https://www.ncbi.nlm.nih.gov/pubmed/16027111
http://dx.doi.org/10.1093/nar/gki698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176012/
https://www.ncbi.nlm.nih.gov/pubmed/16027111
http://dx.doi.org/10.1093/nar/gki698

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