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Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor
BACKGROUND: The tumor suppressor gene PTEN has been found mutated in many types of advanced tumors. When introduced into tumor cells that lack the wild-type allele of the gene, exogenous PTEN was able to suppress their ability to grow anchorage-independently, and thus reverted one of the typical cha...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117602/ https://www.ncbi.nlm.nih.gov/pubmed/12113656 http://dx.doi.org/10.1186/1471-2199-3-11 |