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Improvement of Drosophila acetylcholinesterase stability by elimination of a free cysteine

BACKGROUND: Acetylcholinesterase is irreversibly inhibited by organophosphate and carbamate insecticides allowing its use for residue detection with biosensors. Drosophila acetylcholinesterase is the most sensitive enzyme known and has been improved by in vitro mutagenesis. However, it is not suffic...

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Detalles Bibliográficos
Autores principales: Fremaux, Isabelle, Mazères, Serge, Brisson-Lougarre, Andrée, Arnaud, Muriel, Ladurantie, Caroline, Fournier, Didier
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117796/
https://www.ncbi.nlm.nih.gov/pubmed/12149129
http://dx.doi.org/10.1186/1471-2091-3-21