Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes

BACKGROUND: Antibody genes are diversified by somatic hypermutation (SHM), gene conversion and class-switch recombination. All three processes are initiated by the activation-induced deaminase (AID). According to a DNA deamination model of SHM, AID converts cytosine to uracil in DNA sequences. The i...

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Detalles Bibliográficos
Autores principales: Mayorov, Vladimir I, Rogozin, Igor B, Adkison, Linda R, Frahm, Christin, Kunkel, Thomas A, Pavlov, Youri I
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180437/
https://www.ncbi.nlm.nih.gov/pubmed/15949042
http://dx.doi.org/10.1186/1471-2172-6-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180437/
https://www.ncbi.nlm.nih.gov/pubmed/15949042
http://dx.doi.org/10.1186/1471-2172-6-10

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