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Predicting specificity-determining residues in two large eukaryotic transcription factor families

Certain amino acid residues in a protein, when mutated, change the protein's function. We present an improved method of finding these specificity-determining positions that uses all the protein sequence data available for a family of homologous proteins. We study in detail two families of eukar...

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Detalles Bibliográficos
Autores principales: Donald, Jason E., Shakhnovich, Eugene I.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183107/
https://www.ncbi.nlm.nih.gov/pubmed/16085755
http://dx.doi.org/10.1093/nar/gki755