Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability

Interactions with co-factors provide a means by which HOX proteins exert specificity. To identify candidate protein interactors of HOXA13, we created and screened an E11.5–E12.5, distal limb bud yeast two-hybrid prey library. Among the interactors, we isolated the BMP-signaling effector Smad5, which...

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Detalles Bibliográficos
Autores principales: Williams, Thomas M., Williams, Melissa E., Heaton, Joanne H., Gelehrter, Thomas D., Innis, Jeffrey W.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183491/
https://www.ncbi.nlm.nih.gov/pubmed/16087734
http://dx.doi.org/10.1093/nar/gki761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183491/
https://www.ncbi.nlm.nih.gov/pubmed/16087734
http://dx.doi.org/10.1093/nar/gki761

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