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Susceptibility to Superhelically Driven DNA Duplex Destabilization: A Highly Conserved Property of Yeast Replication Origins

Strand separation is obligatory for several DNA functions, including replication. However, local DNA properties such as A+T content or thermodynamic stability alone do not determine the susceptibility to this transition in vivo. Rather, superhelical stresses provide long-range coupling among the tra...

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Detalles Bibliográficos
Autores principales: Ak, Prashanth, Benham, Craig J
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183513/
https://www.ncbi.nlm.nih.gov/pubmed/16103908
http://dx.doi.org/10.1371/journal.pcbi.0010007