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Changes in P-glycoprotein activity are mediated by the growth of a tumour cell line as multicellular spheroids
BACKGROUND: Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular spheroids is not well understood. Recent evidence suggests that P-gp activity may b...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1185553/ https://www.ncbi.nlm.nih.gov/pubmed/16001980 http://dx.doi.org/10.1186/1475-2867-5-20 |