Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency

BACKGROUND: Mutations in a small region of the rpoB gene are responsible for most rifamycin resistance in Mycobacterium tuberculosis. In this study we have sequentially generated resistant strains to first rifampicin and then rifabutin. Portions of the rpoB gene were sequenced from 131 randomly sele...

Descripción completa

Detalles Bibliográficos
Autores principales: Anthony, Richard M, Schuitema, Anja RJ, Bergval, Indra L, Brown, Tim J, Oskam, Linda, Klatser, Paul R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188052/
https://www.ncbi.nlm.nih.gov/pubmed/15958167
http://dx.doi.org/10.1186/1476-0711-4-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188052/
https://www.ncbi.nlm.nih.gov/pubmed/15958167
http://dx.doi.org/10.1186/1476-0711-4-9

Ejemplares similares