Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo

RNA interference (RNAi) has become an invaluable tool for functional genomics. A critical use of this tool depends on an understanding of the factors that determine the specificity and activity of the active agent, small interfering RNA (siRNA). Several studies have concluded that tolerance of mutat...

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Detalles Bibliográficos
Autores principales: Holen, Torgeir, Moe, Svein Erik, Sørbø, Jan Gunnar, Meza, Trine J., Ottersen, Ole Petter, Klungland, Arne
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188085/
https://www.ncbi.nlm.nih.gov/pubmed/16113241
http://dx.doi.org/10.1093/nar/gki785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188085/
https://www.ncbi.nlm.nih.gov/pubmed/16113241
http://dx.doi.org/10.1093/nar/gki785

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