Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation

BACKGROUND: The active copy of the imprinted gene H19 is turned off by inappropriate methylation in several pediatric tumors including Wilms' Tumour and embryonal rhabdomyosarcoma. H19 controls in cis the linked Insulin-like Growth Factor 2 (IGF2) gene, encoding an important growth factor. Rece...

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Detalles Bibliográficos
Autores principales: Lynch, Catherine A, Tycko, Benjamin, Bestor, Timothy H, Walsh, Colum P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC119368/
https://www.ncbi.nlm.nih.gov/pubmed/12234381
http://dx.doi.org/10.1186/1476-4598-1-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC119368/
https://www.ncbi.nlm.nih.gov/pubmed/12234381
http://dx.doi.org/10.1186/1476-4598-1-2

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