Molecular Origin of Polyglutamine Aggregation in Neurodegenerative Diseases

Expansion of polyglutamine (polyQ) tracts in proteins results in protein aggregation and is associated with cell death in at least nine neurodegenerative diseases. Disease age of onset is correlated with the polyQ insert length above a critical value of 35–40 glutamines. The aggregation kinetics of...

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Detalles Bibliográficos
Autores principales: Khare, Sagar D, Ding, Feng, Gwanmesia, Kenneth N, Dokholyan, Nikolay V
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193989/
https://www.ncbi.nlm.nih.gov/pubmed/16158094
http://dx.doi.org/10.1371/journal.pcbi.0010030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193989/
https://www.ncbi.nlm.nih.gov/pubmed/16158094
http://dx.doi.org/10.1371/journal.pcbi.0010030

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