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Molecular Origin of Polyglutamine Aggregation in Neurodegenerative Diseases
Expansion of polyglutamine (polyQ) tracts in proteins results in protein aggregation and is associated with cell death in at least nine neurodegenerative diseases. Disease age of onset is correlated with the polyQ insert length above a critical value of 35–40 glutamines. The aggregation kinetics of...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193989/ https://www.ncbi.nlm.nih.gov/pubmed/16158094 http://dx.doi.org/10.1371/journal.pcbi.0010030 |