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The Gumbel pre-factor k for gapped local alignment can be estimated from simulations of global alignment
The optimal gapped local alignment score of two random sequences follows a Gumbel distribution. The Gumbel distribution has two parameters, the scale parameter λ and the pre-factor k. Presently, the basic local alignment search tool (BLAST) programs (BLASTP (BLAST for proteins), PSI-BLAST, etc.) use...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199557/ https://www.ncbi.nlm.nih.gov/pubmed/16147981 http://dx.doi.org/10.1093/nar/gki800 |