Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility

Escherichia coli endonuclease VIII (Nei) excises oxidized pyrimidines from DNA. It shares significant sequence homology and similar mechanism with Fpg, a bacterial 8-oxoguanine glycosylase. The structure of a covalent Nei–DNA complex has been recently determined, revealing critical amino acid residu...

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Detalles Bibliográficos
Autores principales: Golan, Gali, Zharkov, Dmitry O., Feinberg, Hadar, Fernandes, Andrea S., Zaika, Elena I., Kycia, Jadwiga H., Grollman, Arthur P., Shoham, Gil
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199562/
https://www.ncbi.nlm.nih.gov/pubmed/16145054
http://dx.doi.org/10.1093/nar/gki796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199562/
https://www.ncbi.nlm.nih.gov/pubmed/16145054
http://dx.doi.org/10.1093/nar/gki796

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