CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection

BACKGROUND: Stable simultaneous knock down of the HIV-1 coreceptors CCR5 and CXCR4 is a promising strategy to protect cells from both R5 macrophage tropic and X4 T cell tropic as well as dual tropic viral infections. The potency of shRNAs in targeted gene silencing qualifies them as powerful tools f...

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Detalles Bibliográficos
Autores principales: Anderson, Joseph, Akkina, Ramesh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199620/
https://www.ncbi.nlm.nih.gov/pubmed/16109172
http://dx.doi.org/10.1186/1742-4690-2-53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199620/
https://www.ncbi.nlm.nih.gov/pubmed/16109172
http://dx.doi.org/10.1186/1742-4690-2-53

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