Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo

BACKGROUND: Huntingtin, the HD gene encoded protein mutated by polyglutamine expansion in Huntington's disease, is required in extraembryonic tissues for proper gastrulation, implicating its activities in nutrition or patterning of the developing embryo. To test these possibilities, we have use...

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Detalles Bibliográficos
Autores principales: Woda, Juliana M, Calzonetti, Teresa, Hilditch-Maguire, Paige, Duyao, Mabel P, Conlon, Ronald A, MacDonald, Marcy E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1208873/
https://www.ncbi.nlm.nih.gov/pubmed/16109169
http://dx.doi.org/10.1186/1471-213X-5-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1208873/
https://www.ncbi.nlm.nih.gov/pubmed/16109169
http://dx.doi.org/10.1186/1471-213X-5-17

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