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The sacrificial role of easily oxidizable sites in the protection of DNA from damage
It has been suggested that DNA contains sacrificial nucleobase sequences that protect sensitive regions of the genome from oxidative damage. Oxidation of DNA by loss of an electron generates a radical cation that can migrate long distances by hopping. The radical cation can be trapped irreversibly a...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1214542/ https://www.ncbi.nlm.nih.gov/pubmed/16157862 http://dx.doi.org/10.1093/nar/gki801 |