Viral mutations enhance the Max binding properties of the vMyc b-HLH-LZ domain

Interaction with Max via the helix–loop–helix/leucine zipper (HLH-LZ) domain is essential for Myc to function as a transcription factor. Myc is commonly upregulated in tumours, however, its activity can also be potentiated by virally derived mutations. vMyc, derived from the virus, MC29 gag-Myc, dif...

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Detalles Bibliográficos
Autores principales: Crouch, D. H., Fisher, F., La Rocca, S. A., Goding, C. R., Gillespie, D. A. F.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1216337/
https://www.ncbi.nlm.nih.gov/pubmed/16166655
http://dx.doi.org/10.1093/nar/gki832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1216337/
https://www.ncbi.nlm.nih.gov/pubmed/16166655
http://dx.doi.org/10.1093/nar/gki832

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