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Viral mutations enhance the Max binding properties of the vMyc b-HLH-LZ domain
Interaction with Max via the helix–loop–helix/leucine zipper (HLH-LZ) domain is essential for Myc to function as a transcription factor. Myc is commonly upregulated in tumours, however, its activity can also be potentiated by virally derived mutations. vMyc, derived from the virus, MC29 gag-Myc, dif...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1216337/ https://www.ncbi.nlm.nih.gov/pubmed/16166655 http://dx.doi.org/10.1093/nar/gki832 |