The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells

BACKGROUND: The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the SCF(SKP2) ubiquitin...

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Detalles Bibliográficos
Autores principales: Lu, Lifang, Schulz, Holger, Wolf, Dieter A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122093/
https://www.ncbi.nlm.nih.gov/pubmed/12188931
http://dx.doi.org/10.1186/1471-2121-3-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122093/
https://www.ncbi.nlm.nih.gov/pubmed/12188931
http://dx.doi.org/10.1186/1471-2121-3-22

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