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PKQuest: measurement of intestinal absorption and first pass metabolism – application to human ethanol pharmacokinetics
BACKGROUND: PKQuest, a new physiologically based pharmacokinetic (PBPK) program, is applied to human ethanol data. The classical definition of first pass metabolism (FPM) based on the differences in the area under the curve (AUC) for identical intravenous and oral doses is invalid if the metabolism...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122094/ https://www.ncbi.nlm.nih.gov/pubmed/12182761 http://dx.doi.org/10.1186/1472-6904-2-4 |