Reduced natriuretic response to acute sodium loading in COMT Gene deleted mice

BACKGROUND: The intrarenal natriuretic hormone dopamine (DA) is metabolised by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). Inhibition of COMT, as opposed to MAO, results in a potent natriuretic response in the rat. The present study in anaesthetized homozygous and heterozygous C...

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Detalles Bibliográficos
Autores principales: Odlind, Cecilia, Reenilä, Ilkka, Männistö, Pekka T, Juvonen, Risto, Uhlén, Staffan, Gogos, Joseph A, Karayiorgou, Maria, Hansell, Peter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122096/
https://www.ncbi.nlm.nih.gov/pubmed/12188925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122096/
https://www.ncbi.nlm.nih.gov/pubmed/12188925

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