Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration

BACKGROUND: Inflammation-activated glia are seen in many CNS pathologies and may kill neurons through the release of cytotoxic mediators, such as nitric oxide from inducible NO synthase (iNOS), and possibly superoxide from NADPH oxidase (NOX). We set out to determine the relative role of these speci...

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Detalles Bibliográficos
Autores principales: Mander, Palwinder, Brown, Guy C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232863/
https://www.ncbi.nlm.nih.gov/pubmed/16156895
http://dx.doi.org/10.1186/1742-2094-2-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232863/
https://www.ncbi.nlm.nih.gov/pubmed/16156895
http://dx.doi.org/10.1186/1742-2094-2-20

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