8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSα

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DNA 8-oxoguanine (8-oxoG) causes transversions and is also implicated in frameshifts. We previously identified the dNTP pool as a likely source of mutagenic DNA 8-oxoG and demonstrated that DNA mismatch repair prevented oxidation-related frameshifts in mononucleotide repeats. Here, we show that both...

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Detalles Bibliográficos
Autores principales: Macpherson, Peter, Barone, Flavia, Maga, Giovanni, Mazzei, Filomena, Karran, Peter, Bignami, Margherita
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1233161/
https://www.ncbi.nlm.nih.gov/pubmed/16174844
http://dx.doi.org/10.1093/nar/gki813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1233161/
https://www.ncbi.nlm.nih.gov/pubmed/16174844
http://dx.doi.org/10.1093/nar/gki813

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