Evolutionary conservation suggests a regulatory function of AUG triplets in 5′-UTRs of eukaryotic genes

By comparing sequences of human, mouse and rat orthologous genes, we show that in 5′-untranslated regions (5′-UTRs) of mammalian cDNAs but not in 3′-UTRs or coding sequences, AUG is conserved to a significantly greater extent than any of the other 63 nt triplets. This effect is likely to reflect, pr...

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Detalles Bibliográficos
Autores principales: Churbanov, Alexander, Rogozin, Igor B., Babenko, Vladimir N., Ali, Hesham, Koonin, Eugene V.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236974/
https://www.ncbi.nlm.nih.gov/pubmed/16186132
http://dx.doi.org/10.1093/nar/gki847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236974/
https://www.ncbi.nlm.nih.gov/pubmed/16186132
http://dx.doi.org/10.1093/nar/gki847

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