A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation

The phylogenetically-derived secondary structures of telomerase RNAs (TR) from ciliates, yeasts and vertebrates are surprisingly conserved and contain a pseudoknot domain at a similar location downstream of the template. As the pseudoknot domains of Tetrahymena TR (tTR) and human TR (hTR) mediate ce...

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Detalles Bibliográficos
Autores principales: Marie-Egyptienne, Delphine T., Cerone, Maria Antonietta, Londoño-Vallejo, J. Arturo, Autexier, Chantal
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236975/
https://www.ncbi.nlm.nih.gov/pubmed/16192571
http://dx.doi.org/10.1093/nar/gki848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236975/
https://www.ncbi.nlm.nih.gov/pubmed/16192571
http://dx.doi.org/10.1093/nar/gki848

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