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Characterization of the bisintercalative DNA binding mode of a bifunctional platinum–acridine agent

The DNA interactions of PT-BIS(ACRAMTU) ([Pt(en)(ACRAMTU)(2)](NO(3))(4); ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea, en = ethylenediamine), a bifunctional platinum–acridine conjugate, have been studied in native and synthetic double-stranded DNAs and model duplexes using various b...

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Detalles Bibliográficos
Autores principales: Choudhury, Jayati Roy, Bierbach, Ulrich
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236979/
https://www.ncbi.nlm.nih.gov/pubmed/16192574
http://dx.doi.org/10.1093/nar/gki869