Natural Variation in Vif: Differential Impact on APOBEC3G/3F and a Potential Role in HIV-1 Diversification

The HIV-1 Vif protein counteracts the antiviral activity exhibited by the host cytidine deaminases APOBEC3G and APOBEC3F. Here, we show that defective vif alleles can readily be found in HIV-1 isolates and infected patients. Single residue changes in the Vif protein sequence are sufficient to cause...

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Detalles Bibliográficos
Autores principales: Simon, Viviana, Zennou, Veronique, Murray, Deya, Huang, Yaoxing, Ho, David D, Bieniasz, Paul D
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1238741/
https://www.ncbi.nlm.nih.gov/pubmed/16201018
http://dx.doi.org/10.1371/journal.ppat.0010006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1238741/
https://www.ncbi.nlm.nih.gov/pubmed/16201018
http://dx.doi.org/10.1371/journal.ppat.0010006

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