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In vitro selection of RNA aptamers against a composite small molecule-protein surface

A particularly challenging problem in chemical biology entails developing systems for modulating the activity of RNA using small molecules. One promising new approach towards this problem exploits the phenomenon of ‘surface borrowing,’ in which the small molecule is presented to the RNA in complex w...

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Detalles Bibliográficos
Autores principales: Plummer, Kelly A., Carothers, James M., Yoshimura, Masahiro, Szostak, Jack W., Verdine, Gregory L.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240114/
https://www.ncbi.nlm.nih.gov/pubmed/16199752
http://dx.doi.org/10.1093/nar/gki867