Mechanistic features of CAG•CTG repeat contractions in cultured cells revealed by a novel genetic assay

Trinucleotide repeats (TNRs) undergo high frequency mutagenesis to cause at least 15 neurodegenerative diseases. To understand better the molecular mechanisms of TNR instability in cultured cells, a new genetic assay was created using a shuttle vector. The shuttle vector contains a promoter-TNR-repo...

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Detalles Bibliográficos
Autores principales: Pelletier, Richard, Farrell, Brian T., Miret, Juan José, Lahue, Robert S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240116/
https://www.ncbi.nlm.nih.gov/pubmed/16199754
http://dx.doi.org/10.1093/nar/gki880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240116/
https://www.ncbi.nlm.nih.gov/pubmed/16199754
http://dx.doi.org/10.1093/nar/gki880

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