Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats.

We studied the pharmacokinetics of dichloroacetate (DCA) in naive rats and rats depleted of glutathione S-transferase-zeta (GST-zeta), at doses approaching human daily exposure levels. We also compared in vitro metabolism of DCA by rat and human liver cytosol. Jugular vein-cannulated male Fischer-34...

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Detalles Bibliográficos
Autores principales: Saghir, Shakil A, Schultz, Irvin R
Formato: Texto
Lenguaje:English
Publicado: 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240945/
https://www.ncbi.nlm.nih.gov/pubmed/12153755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240945/
https://www.ncbi.nlm.nih.gov/pubmed/12153755

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