Reductive activation with cysteine represents a chromium(III)-dependent pathway in the induction of genotoxicity by carcinogenic chromium(VI).

Induction of DNA damage by carcinogenic hexavalent chromium compounds [Cr(VI)] results from its reduction to lower oxidation states. Reductive metabolism of Cr(VI) generates intermediate Cr(V/IV)species, organic radicals, and finally Cr(III), which forms stable complexes with many biological ligands...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhitkovich, Anatoly, Quievryn, George, Messer, Joseph, Motylevich, Zhanna
Formato: Texto
Lenguaje:English
Publicado: 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241234/
https://www.ncbi.nlm.nih.gov/pubmed/12426121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241234/
https://www.ncbi.nlm.nih.gov/pubmed/12426121

Ejemplares similares