Oxidative DNA adducts and DNA-protein cross-links are the major DNA lesions induced by arsenite.

Arsenic is recognized to be a nonmutagenic carcinogen because it induces DNA damage only at very high concentrations. However, many more DNA strand breaks could be detected by digesting the DNA of arsenite-treated cells with endonuclease III, formamidopyrimidine-DNA glycosylase, and proteinase K. By...

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Detalles Bibliográficos
Autores principales: Bau, Da-Tian, Wang, Tsu-Shing, Chung, Chiao-Hui, Wang, Alexander S S, Jan, Kun-Yan
Formato: Texto
Lenguaje:English
Publicado: 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241239/
https://www.ncbi.nlm.nih.gov/pubmed/12426126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241239/
https://www.ncbi.nlm.nih.gov/pubmed/12426126

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