Inhibition of Ape1 nuclease activity by lead, iron, and cadmium.

Many environmental metals are co-carcinogens, eliciting their effects via inhibition of DNA repair. Apurinic/apyrimidinic (AP) endonuclease 1 (Ape1) is the major mammalian abasic endonuclease and initiates repair of this cytotoxic/mutagenic lesion by incising the DNA backbone via a Mg(2+)-dependent...

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Detalles Bibliográficos
Autores principales: McNeill, Daniel R, Narayana, Avinash, Wong, Heng-Kuan, Wilson, David M
Formato: Texto
Lenguaje:English
Publicado: 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241995/
https://www.ncbi.nlm.nih.gov/pubmed/15159209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241995/
https://www.ncbi.nlm.nih.gov/pubmed/15159209

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