PCNA–MutSα-mediated binding of MutLα to replicative DNA with mismatched bases to induce apoptosis in human cells

Modified bases, such as O(6)-methylguanines, are produced in cells exposed to alkylating agents and cause apoptosis. In human cells treated with N-methyl-N-nitrosourea, we detected a protein complex composed of MutSα, MutLα and PCNA on damaged DNA by immunoprecipitation method using chromatin extrac...

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Detalles Bibliográficos
Autores principales: Hidaka, Masumi, Takagi, Yasumitsu, Takano, Tomoko Y., Sekiguchi, Mutsuo
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1243802/
https://www.ncbi.nlm.nih.gov/pubmed/16204460
http://dx.doi.org/10.1093/nar/gki878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1243802/
https://www.ncbi.nlm.nih.gov/pubmed/16204460
http://dx.doi.org/10.1093/nar/gki878

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