Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD)

BACKGROUND: TP53 is an attractive candidate for modifying age of onset (AO) in Huntington disease (HD): The amino-terminus of the mutated huntingtin (htt) exon 1 translation product has functional properties which may affect critically the TP53 pathway in HD neurons. The pathogenic domain of mutant...

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Detalles Bibliográficos
Autores principales: Arning, Larissa, Kraus, Peter H, Saft, Carsten, Andrich, Jürgen, Epplen, Jörg T
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253512/
https://www.ncbi.nlm.nih.gov/pubmed/16202123
http://dx.doi.org/10.1186/1471-2350-6-35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253512/
https://www.ncbi.nlm.nih.gov/pubmed/16202123
http://dx.doi.org/10.1186/1471-2350-6-35

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